Categories
(5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester
- CAS: 365998-36-3
- Purity: 99%
- Reputable supplier selling (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester 365998-36-3 with stock
Reputable supplier selling (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester 365998-36-3 with stock
- Molecular Formula: C14H27N3O3
- Molecular Weight: 285.387
- Boiling Point: 434.4±45.0 °C(Predicted)
- PKA: 11.90±0.60(Predicted)
- PSA： 88.15000
- Density: 1.09±0.1 g/cm3(Predicted)
- LogP: 2.00000
365998-36-3 Relevant articles
Method for preparing eteaban chiral amine intermediate (by machine translation)
-
Paragraph 0059-0069, (2020/09/12)
The invention provides a safe and conven...
Preparation method of edoxaban intermediate
-
, (2020/09/12)
The invention relates to the technical f...
Preparation method and intermediate of chiral diamine compound
-
Paragraph 0046; 0047; 0048, (2019/07/04)
The present invention relates to a prepa...
Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban
Michida, Makoto,Ishikawa, Hideaki,Kaneda, Takeshi,Tatekabe, Shinya,Nakamura, Yoshitaka
, p. 524 - 534 (2019/03/07)
We report the development of a novel syn...
365998-36-3 Process route
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![tert-butyl N-[(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate](/upload/2026/6/1030d84ce76f45afbbe60495c532f936_ce5504b5-c701-43c9-b83b-35a73d69fc67.png)
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480450-69-9
tert-butyl N-[(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate
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-
365998-36-3
(1S,2R,4S)-N2 -(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine
| Conditions | Yield |
|---|---|
|
With
methanol; palladium 10% on activated carbon; hydrogen;
at 50 - 60 ℃;
under 3000.3 - 4500.45 Torr;
Temperature;
Reagent/catalyst;
|
87.7%
|
|
With
ammonium formate;
palladium-carbon;
In
methanol; acetonitrile;
at 40 ℃;
for 1h;
|
|
|
With
palladium-carbon; ammonium formate;
In
methanol;
at 40 ℃;
for 1h;
|
-
-
(1S,2R,4S)-N1 -Benzyloxycarbonyl-N2 -(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine
-
-
365998-36-3
(1S,2R,4S)-N2 -(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine
| Conditions | Yield |
|---|---|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 3h;
under 5320.36 Torr;
|
93%
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 3h;
under 5320.36 Torr;
|
|
|
palladium;
In
methanol; hexane; toluene;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 3h;
under 5320.36 Torr;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran;
at 20 ℃;
|
365998-36-3 Upstream products
-
480450-69-9
tert-butyl N-[(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate
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929693-35-6
(1S,3S,6R)-N,N-dimethyl-7-oxabicyclo[4.1.0]heptane-3-carboxamide
-
929693-36-7
(1S,3R,4R)-3-amino-4-hydroxy-N,N-dimethyl cyclohexanecarboxamide
-
929693-30-1
(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide
365998-36-3 Downstream products
-
480452-40-2
tert-Butyl (1R,2S,5S)-5-[(dimethylamino)carbonyl]-2-{[2-(4-fluoroanilino)-2-oxoethanethioyl]amino}cyclohexyl-carbamate
-
480449-95-4
(1S,2R,4S)-N2 -(tert-Butoxycarbonyl)-N1 -[(6-chloro-quinolin-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine
-
480451-79-4
tert-Butyl (1R,2S,5S)-2-{[2-(4-chloroanilino)-2-(hydroxyimino)acetyl]amino}-5-[(dimethylamino)carbonyl]-cyclohexylcarbamate
-
500571-54-0
Methyl 2-[((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)amino]-2-(methoxyimino)-acetate
