Pharmaceutical

PORPHINE

  • CAS: 101-60-0
  • Purity: 99%
  • Cosmetics Grade PORPHINE 101-60-0 For Sale with Good Price
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Cosmetics Grade PORPHINE 101-60-0 For Sale with Good Price

  • Molecular Formula: C20H14N4
  • Molecular Weight: 310.358
  • Vapor Pressure: 0mmHg at 25°C 
  • Melting Point: 360°C 
  • Refractive Index: 1.72 
  • Boiling Point: 804.4 °C at 760 mmHg 
  • Flash Point: 377.479 °C 
  • PSA: 56.30000 
  • Density: 1.353 g/cm3 
  • LogP: 1.19220 

PORPHINE(Cas 101-60-0) Usage

History

Porphine was first prepared by German chemists Hans Fischer and Wilhelm Gleim in 1935. It is the parent structure of a large family of natural compounds called porphyrins, many of which are essential to life. Fischer was a 1930 Nobel Prize winner for his research on two porphyrins, heme (a constituent of hemoglobin) and chlorophyll. These porphyrins, like many others, contain a metal atom coordinated to the four nitrogen atoms.

Chemical Synthesis

Porphine is the simplest porphyrin and represents the core macrocycle of naturally occurring and synthetic porphyrins. Low yields and expense, however, make the synthesis of porphine on a large scale impractical. Another challenge synthetic chemist's faced was the high insolubility of porphine. The apolar tetrapyrrolic ring structure of porphine means it is poorly soluble in most organic solvents and hardly water soluble. As a result of this almost all current chemical studies with porphyrins use the better soluble meso tetrasubstituted 2 or β-octasubstituted porphyrins.

InChI:InChI=1/C20H14N4/c1-2-14-10-16-5-6-18(23-16)12-20-8-7-19(24-20)11-17-4-3-15(22-17)9-13(1)21-14/h1-12,21,24H/b13-9-,14-10-,15-9-,16-10-,17-11-,18-12-,19-11-,20-12-

101-60-0 Relevant articles

Convenient synthesis of porphine from β-tetra(tert-butyl)porphyrin

Neya, Saburo,Quan, Jingshun,Hoshino, Tyuji,Hata, Masayuki,Funasaki, Noriaki

, p. 8629 - 8630 (2004)

β-Tetra(tert-butyl)porphyrin was prepare...

Protonation salt derivative with heavy-atom effect on phthalocyanine for enhanced in vitro photodynamic therapy

Chen, Xianglan,Li, Yejing,Wang, Ao,Zhou, Lin,Lu, Shan,Zhou, Jiahong,Lin, Yun,Wei, Shaohua

, p. 93 - 104 (2015)

In order to improve water-solubility and...

Inducing Open-Shell Character in Porphyrins through Surface-Assisted Phenalenyl π-Extension

Bottari, Giovanni,Fasel, Roman,Lorente, Nicolas,Mateo, Luis M.,Robles, Roberto,Ruffieux, Pascal,Sun, Qiang,Torres, Tomás

, p. 18109 - 18117 (2020)

Organic open-shell compounds are extraor...

-

Hodgson,Baker

, p. 29,30,31 (1967)

-

meso-tetra(tert-butyl)porphyrin as a precursor of porphine

Neya, Saburo,Funasaki, Noriaki

, p. 1057 - 1058 (2002)

Treatment of meso-tetra(tert-butyl)porph...

Direct synthesis of magnesium porphine via 1-formyldipyrromethane

Dogutan, Dilek Kiper,Ptaszek, Marcin,Lindsey, Jonathan S.

, p. 5008 - 5011 (2007)

(Chemical Equation Presented) The reacti...

A facile route to tripyrrane from 2,5-bis(hydroxymethyl)pyrrole and the improved synthesis of porphine by the '3+1' approach

Taniguchi, Shozo,Hasegawa, Hikaru,Nishimura, Masato,Takahashi, Masahiko

, p. 73 - 74 (1999)

The treatment of 2,5-bis(hydroxymethyl)p...

Porphine and pyrrole-substituted porphyrin from cyclocondensation of tripyrrane with mono-substituted pyrroles

Saltsman, Irena,Goldberg, Israel,Balasz, Yael,Gross, Zeev

, p. 239 - 244 (2007)

The condensation of non-substituted trip...

A novel and efficient synthesis of porphine

Neya, Saburo,Quan, Jingshun,Hata, Masayuki,Hoshino, Tyuji,Funasaki, Noriaki

, p. 8731 - 8732 (2006)

meso-Tetra(n-hexyloxycarbonyl)porphyrin ...

The facile synthesis of 5-formylporphyrin

Liu, Peng Peng,Feng, Ya Qing,Gu, Cheng Zhi,Meng, Shu Xian,Zhang, Bao

, p. 505 - 508 (2012)

A facile synthetic route of 5-formylporp...

High-Resolution Solid-State 13C NMR Spectra of Porphine and 5,10,15,20-Tetraalkylporphyrins: Implications for the N-H Tautomerization Process

Frydman, Lucio,Olivieri, Alejandro C.,Diaz, Luis E.,Frydman, Benjamin,Morin, Frederick G.,et al.

, p. 336 - 342 (1988)

The solid-state high-resolution 13C nucl...

-

Rothemund

, (1939)

-

Concerning the Crystal Structure of Porphine: A Proton Pulsed and 13C CPMAS NMR Study

Frydman, Lucio,Olivieri, Alejandro C.,Diaz, Luis E.,Frydman, Benjamin,Kustanovich, Irina,Vega, Shimon

, p. 7001 - 7005 (1989)

Solid-state NMR techniques were employed...

-

Dicker et al.

, p. 560 (1967)

-

-

Krol

, p. 2065 (1959)

-

The influence of protonation on the structure and spectral properties of porphine: UV-vis, 1H NMR and: Ab initio studies

Zakavi, Saeed,Omidyan, Reza,Talebzadeh, Sadegh

, p. 82219 - 82226 (2016/09/09)

In this study, protonation of porphine (...

Soluble porphyrin polymers

-

Page/Page column, (2015/07/15)

Porphyrin polymers of Structure 1, where...

101-60-0 Process route

4-(4-((tritylamino)methyl)phenoxy)phthalonitrile

4-(4-((tritylamino)methyl)phenoxy)phthalonitrile

porphyrin
101-60-0

porphyrin

Conditions
Conditions Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In n-heptan1ol;
80%
2-hydroxymethylpyrrole
27472-36-2

2-hydroxymethylpyrrole

porphyrin
101-60-0

porphyrin

Conditions
Conditions Yield
With dipotassium peroxodisulfate; magnesium acetate;
With acetic acid; In xylene; at 110 - 115 ℃;
With acetic acid; In xylene; at 110 - 115 ℃; Heating;
Multi-step reaction with 2 steps
1: aq. sodium dodecyl sulfate, HCl / 0.17 h
2: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H2 O; tetrahydrofuran / 0.5 h
With hydrogenchloride; sodium dodecyl-sulfate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; water;

101-60-0 Upstream products

  • 1003-29-8
    1003-29-8

    2-pyrrole aldehyde

  • 64-18-6
    64-18-6

    formic acid

  • 64-17-5
    64-17-5

    ethanol

  • 488-92-6
    488-92-6

    3-ethyl-4-methyl-1H-pyrrole

101-60-0 Downstream products

  • 25440-14-6
    25440-14-6

    tetrakis(pentafluorophenyl)porphyrin

  • 22112-84-1
    22112-84-1

    tetrakis(4-aminophenyl)porphyrin

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