Licofelone

Factory supply Licofelone 156897-06-2 with sufficient production capacity We provide high quality Licofelone (CAS 156897-06-2), at a very affordable prices to our customers.

1.What is the Licofelone ?

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.

2.What is the CAS number for Licofelone ?

The CAS number of Licofelone is 156897-06-2.

More information of Licofelone 156897-06-2 are:

3.What is the molecular formula of Licofelone ?

The chemical formula of?Licofelone is C23H22ClNO2 which containing 23 Carbon atoms,22 Hydrogen atoms,1 Chlorine atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of Licofelone is 379.886

4.What is Licofelone(156897-06-2)used for?

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

InChI:InChI=1/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)

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5.Factory supply Licofelone 156897-06-2 with sufficient production capacity

Neworld Chemical Co., Ltd Shanghai is a quality supplier of Licofelone. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Licofelone 156897-06-2.