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GSK J4 HCl
- CAS: 1373423-53-0
- Purity: 99%
- Reputable factory supply GSK J4 HCl 1373423-53-0 in stock with high standard
Reputable factory supply GSK J4 HCl 1373423-53-0 in stock with high standard We supply high quality GSK J4 HCl (CAS 1373423-53-0), in stock, factory directly supply to clients, lower prices, more competitiveness.
What is the GSK J4 HCl ?
GSK J4 HCl is , while it's Molecular Formula is C24H27N5O2. GSK-J4 has been used to study the effect of KDM2B (Jumonji (JmjC) domain histone 3 lysine 36 (H3K36) di-demethylase) inhibition on the survival and DNA repair potential of glioblastoma cells. It has also been used in sulforhodamine B (SRB) cell growth assay and cell viability assay.
What is the CAS number for GSK J4 HCl ?
The CAS number of GSK J4 HCl is 1373423-53-0.
More information of GSK J4 HCl 1373423-53-0 are:
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Synonyms |
GSK J4 HCl;GSK J4;GSK-J4;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine ethyl ester;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester, hydrochloride (1:1) |
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CAS?Number |
1373423-53-0 |
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Molecular Formula |
C24H27N5O2 |
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Molecular Weight |
417.50348 |
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Density |
1.216±0.06 g/cm3(Predicted) |
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Boiling Point |
581.2±50.0 °C(Predicted) |
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PSA |
80.24000 |
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LogP |
3.64690 |
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Pka |
5.95±0.10(Predicted) |
What is GSK J4 HCl (1373423-53-0) used for?
GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393).1 GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.2
Articles related to GSK J4 HCl:
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Article |
Source |
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Immobilization products and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins |
- , (2013/05/23) |
How to get the best price on GSK J4 HCl?
Neworld Chemical Co., Ltd Shanghai is a quality supplier and manufacturer of GSK J4 HCl . You can buy high quality, low price GSK J4 HCl 1373423-53-0 here. Contact us.
