Categories
(2-chlorophenyl) (1-hydroxycyclopentyl) ketone
- CAS: 90717-17-2
- Purity: 99%
- Factory Export Top Purity (2-chlorophenyl) (1-hydroxycyclopentyl) ketone 90717-17-2 In Stock
Factory Export Top Purity (2-chlorophenyl) (1-hydroxycyclopentyl) ketone 90717-17-2 In Stock
- Molecular Formula: C12H13ClO2
- Molecular Weight: 224.687
- Vapor Pressure: 6.19E-05mmHg at 25°C
- Boiling Point: 331.5°Cat760mmHg
- PKA: 13.10±0.20(Predicted)
- Flash Point: 154.3°C
- PSA： 37.30000
- Density: 1.297g/cm3
- LogP: 2.82780
(2-chlorophenyl) (1-hydroxycyclopentyl) ketone(Cas 90717-17-2) Usage
InChI:InChI=1/C12H13ClO2/c13-10-6-2-1-5-9(10)11(14)12(15)7-3-4-8-12/h1-2,5-6,15H,3-4,7-8H2
90717-17-2 Relevant articles
Process Research and Impurity Control Strategy of Esketamine
Gao, Shenghua,Gao, Xuezhi,Yang, Zhezhou,Zhang, Fuli
, p. 555 - 566 (2020/05/19)
An improved synthesis of (S)-ketamine (e...
Catalytic Asymmetric Acyloin Rearrangements of α-Ketols, α-Hydroxy Aldehydes, and α-Iminols by N, N′-Dioxide-Metal Complexes
Dai, Li,Li, Xiangqiang,Zeng, Zi,Dong, Shunxi,Zhou, Yuqiao,Liu, Xiaohua,Feng, Xiaoming
, p. 5041 - 5045 (2020/07/03)
A highly enantioselective acyloin rearra...
Expedient preparation of active pharmaceutical ingredient ketamine under sustainable continuous flow conditions
Kassin, Victor-Emmanuel H.,Gérardy, Romaric,Toupy, Thomas,Collin, DIégo,Salvadeo, Elena,Toussaint, Fran?ois,Van Hecke, Kristof,Monbaliu, Jean-Christophe M.
supporting information, p. 2952 - 2966 (2019/06/18)
A robust three-step continuous flow proc...
IMPROVEMENTS IN OR RELATING TO ORGANIC MATERIAL
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Page/Page column 20-24, (2019/07/17)
The invention provides a method for synt...
90717-17-2 Process route
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1-((2-chlorophenyl)(methylimino)methyl)cyclopentanol hydrochloride
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90717-17-2
(±)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone
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1867-66-9
(+/-)-ketamine hydrochloride
| Conditions | Yield |
|---|---|
|
With
benzoic acid ethyl ester;
at 140 ℃;
for 18h;
Temperature;
Inert atmosphere;
|
77.1 %Chromat.
22.7 %Chromat. |
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6740-85-8
(2-chlorophenyl)(cyclopentyl)methanone
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90717-17-2
(±)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone
| Conditions | Yield |
|---|---|
|
With
oxygen; potassium hydroxide; triethyl phosphite;
In
ethanol;
at 25 ℃;
for 0.0833333h;
under 8250.83 Torr;
Temperature;
Pressure;
Reagent/catalyst;
Solvent;
Flow reactor;
|
|
|
With
18-crown-6 ether; potassium tert-butylate; oxygen; triethyl phosphite;
In
ethanol;
at 30 ℃;
for 0.0833333h;
under 8274.59 Torr;
Reagent/catalyst;
Solvent;
Wavelength;
Temperature;
Pressure;
Flow reactor;
|
|
|
Multi-step reaction
with
2
steps
1: hydrogen bromide; dihydrogen peroxide / water / 3 h / 70 - 80 °C
2: water / 80 h / 5 °C
With
water; hydrogen bromide; dihydrogen peroxide;
In
water;
|
|
|
Multi-step reaction
with
2
steps
1: hydrogen bromide; dihydrogen peroxide / water / 3 h / 70 - 80 °C
2: water / tetrahydrofuran / 24 h / 25 °C
With
water; hydrogen bromide; dihydrogen peroxide;
In
tetrahydrofuran; water;
|
|
|
Multi-step reaction
with
2
steps
1: acetic acid; bromine / dichloromethane / 0 - 20 °C
2: ammonium hydroxide / 48 h / 20 °C
With
ammonium hydroxide; bromine; acetic acid;
In
dichloromethane;
|
90717-17-2 Upstream products
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6740-85-8
(2-chlorophenyl)(cyclopentyl)methanone
-
873-32-5
2-Chlorobenzonitrile
-
6740-86-9
(1-Bromocyclopentyl)(2-chlorophenyl)methanone
-
74-89-5
methylamine
