What is the CAS number for SR8278?

The CAS number of SR8278 is 1254944-66-5.

What is SR8278 (1254944-66-5) used for?

REV-ERBa is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBa (EC50 = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBa target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBa in regulating glucagon secretion in pancreatic alpha cells.

What is the CAS number for SR8278?

The CAS number of SR8278 is 1254944-66-5.

What is SR8278 (1254944-66-5) used for?

REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.

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SR8278

CAS: 1254944-66-5
Purity: 99%
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What is the SR8278 ?

SR8278 is , while it's Molecular Formula is C18H19NO3S2. SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.

How to get the best price on SR8278?

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