Pharmaceutical

Chlorodifluoroacetic acid ethyl ester

  • CAS: 383-62-0
  • Purity: 99%
  • Quality Manufacturer Supply High Purity 99% Chlorodifluoroacetic acid ethyl ester 383-62-0 with Reasonable Price
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Quality Manufacturer Supply High Purity 99% Chlorodifluoroacetic acid ethyl ester 383-62-0 with Reasonable Price

  • Molecular Formula: C4H5ClF2O2
  • Molecular Weight: 158.532
  • Appearance/Colour: clear colorless liquid 
  • Refractive Index: n20/D 1.358(lit.)  
  • Boiling Point: 93.8 °C at 760 mmHg 
  • Flash Point: 28.9 °C 
  • PSA: 26.30000 
  • Density: 1.316 g/cm3 
  • LogP: 1.38110 

Chlorodifluoroacetic acid ethyl ester(Cas 383-62-0) Usage

General Description

Ethyl chlorodifluoroacetate (ECDFA) undergoes Reformatskii reaction with various aldehydes in DMF. It reacts with phenylacetylene to afford ethyl α,α?difluoro-4-phenyl-3-butenoates.

InChI:InChI=1/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3

383-62-0 Relevant articles

METHOD FOR PRODUCING DIFLUORO-ACETYL-ACETIC ACID ALKYLESTERS

-

Page 13, (2008/06/13)

The invention relates to a three-stage m...

Synthesis, characterisation and mass spectrometric fragmentation of O-(chlorodifluoroacylated) alcohols

Bhadury, Pinaki S.,Palit, Meehir,Sharma, Mamta,Raza, Syed K.,Jaiswal, Devendra K.

, p. 47 - 50 (2007/10/03)

An indirect and uncatalysed esterificati...

Process for the preparation of alkyl halodifluoroacetates

-

, (2008/06/13)

For the preparation of alkyl halodifluor...

Process for producing carboxylic acid esters from carboxylic acid halides and alcohols

-

, (2008/06/13)

A process for preparing carboxylic ester...

383-62-0 Process route

ethanol
64-17-5

ethanol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

Conditions
Conditions Yield
With toluene-4-sulfonic acid; In dichloromethane; at 20 - 33 ℃; for 38.5h; Heating / reflux;
78.5%
With sulfuric acid;
chlordifluoroacetyl chloride
354-24-5

chlordifluoroacetyl chloride

ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

Conditions
Conditions Yield
In ethanol;

383-62-0 Upstream products

  • 64-17-5
    64-17-5

    ethanol

  • 76-04-0
    76-04-0

    2-chloro-2,2-difluoroacetic acid

  • 648-48-6
    648-48-6

    1.1.2.2-Tetrafluor-2-chlor-aethylnitrit

  • 1717-64-2
    1717-64-2

    1,2-dichloro-1,1,2-trifluoro-2-nitrosooxy-ethane

383-62-0 Downstream products

  • 721-98-2
    721-98-2

    chloro-difluoro-acetic acid-((S )-1-methyl-2-phenyl-ethylamide)

  • 721-98-2
    721-98-2

    chloro-difluoro-acetic acid-((R )-1-methyl-2-phenyl-ethylamide)

  • 6312-18-1
    6312-18-1

    2-chloro-2,2-difluoro-1,1-diphenyl-ethanol

  • 421-05-6
    421-05-6

    chlorodifluoroacetonitrile

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